update on infantile haemangioma
نویسندگان
چکیده
infantile haemangiomas (ih) are the most common vascular tumors occurring in early childhood, with a prevalence of approximately 5-10% of infants. these vascular tumors are divided into two main groups including infantile haemangioma and vascular malformations. although, haemangioma of infancy are common, benign and self-limited tumors, a significant percent of these lesions are associated with substantial morbidity in infancy and childhood. all currently used treatments have significant risks. dramatic improvement of complicated haemangioma of infancy to propranolol was recently reported. herein, we review infantile haemangioma as a whole with focus on the therapeutic efficacy of systemic and topical propranolol as a beta-blockers for the management of infantile haemangioma.
منابع مشابه
Update on Infantile Haemangioma
Article type: Review Article Infantile Haemangiomas (IH) are the most common vascular tumors occurring in early childhood, with a prevalence of approximately 510% of infants. These vascular tumors are divided into two main groups including; infantile haemangioma and vascular malformations. Although, haemangioma of infancy are common, benign and selflimited tumors, a significant percent of these...
متن کاملHaemogenic endothelium in infantile haemangioma.
BACKGROUND Proliferating infantile haemangioma (IH) is a tumour of the microvasculature composed predominantly of immature endothelial cells. The origin of IH is unclear, but it has been shown to express markers of both endothelial and haematopoietic lineages, and a role for endothelial progenitor cells in the aetiology of IH has been suggested. Haemangioblasts are precursors of both endothelia...
متن کاملInfantile Haemangioma – An unusual location
A “haemangioma”(Greek for blood-vessel-growth) of Infancy is a benign overgrowth of blood vessel cells in the skin. It is also known as proliferative haemangioma because it is due to proliferating endothelial cells; these are the cells that line blood vessels. The incidence ranges from 1% in neonates to 12% [1]. These are known to appear soon after birth, proliferate for 8-18 months, and then s...
متن کاملInfantile haemangioma: a complicated disease.
Infantile haemangiomas (IH) are common benign vascular tumors of childhood. They are characterised by rapid growth during the first year of life and slow regression that is usually completed by 7-10 years of age. The underlying mechanism of action of IH is aberrant angiogenesis and vasculogenesis, and involves the mammalian target of rapamycin pathway and vascular endothelial growth factor path...
متن کاملResearch in infantile haemangioma: local perspectives.
Two articles related to infantile haemangioma (IH) are published in this issue of the Hong Kong Medical Journal. The first was written by a group from Prince of Wales Hospital (PWH) focusing on the clinical and radiological features of IH.1 The second was from the United Christian Hospital (UCH) describing the use of propranolol as treatment.2 How much do these articles contribute to better und...
متن کاملPropranolol in infantile haemangioma: simplifying pretreatment monitoring.
BACKGROUND Infantile haemangiomas (IHs) are very common vascular tumours. Propranolol is at present the first-line treatment for problematic and complicated haemangioma. In accordance with a Swiss protocol, children are monitored for 2 days at the start of the treatment to detect possible side effects of this drug. Our study advocates a simplification of the pretreatment monitoring process. M...
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عنوان ژورنال:
journal of pediatrics reviewجلد ۲، شماره ۱، صفحات ۲۹-۳۸
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